Refine search

Search Natural Substrates/ Products (Substrates)

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search
Search for synonyms (with exact matching search term)

Search term:

Results 1 - 10 of 10
EC Number
Natural Substrates
Commentary (Nat. Sub.)
factor IX
activation of Factor IX in the intrinsic coagulation cascade
factor IX + H2O
-
factor IX + H2O
factor XIa has a role in the intrinsic pathway of coagulation, and plays a significant role in venous thrombosis
factor IX + H2O
factor XIa is essential for the optimal activation of FIX
factor IX + H2O
two forms of activated factor XI are generated during coagulation, and each half of a factor XIa dimer behaves as an independent enzyme with respect to factor IX
factor IX + H2O
after binding to factor XIa, factor IX undergoes a single cleavage to form the intermediate factor IXalpha. FIXalpha then rebinds to the A3 domain to undergo a second cleavage, generating factor IXalphabeta
factor V + H2O
fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348
factor VIII + H2O
fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721
pro-HGF + H2O
the enzyme may regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis
tissue factor pathway inhibitor + H2O
the cleavage of the protein occurs between the Kunitz (K)1 and K2 domains (Lys86/Thr87) and at the active sites of the K2 (Arg107/Gly108) and K3 (Arg199/Ala200) domains
Results 1 - 10 of 10