EC Number   |
Natural Substrates |
|---|
   3.4.17.23 | angiotensin I + H2O |
- |
| 3.4.17.23 | angiotensin II + H2O |
- |
| 3.4.17.23 | more |
a combination of ACE2 and ACE convert amyloid-beta protein 43 to amyloid-beta protein 40 |
| 3.4.17.23 | more |
ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue |
| 3.4.17.23 | angiotensin I + H2O |
ACE2 contributes to the production of angiotensin(1-7) from angiotensin I in proximal straight tubule |
| 3.4.17.23 | amyloid-beta protein 43 + H2O |
ACE2 converts amyloid-beta protein 43 to amyloid-beta protein 42 in mouse brain lysates |
| 3.4.17.23 | more |
ACE2 ectodomain shedding and/or sheddase(s) activation regulated by calmodulin is independent from the phorbol ester-induced shedding |
| 3.4.17.23 | more |
ACE2 is a crucial SARS-CoV receptor. SARS-CoV infections and the Spike protein of the SARS-CoV reduce ACE2 expression. Injection of SARS-CoV Spike into mice worsens acute lung failure in vivo that can be attenuated by blocking the renin-angiotensin pathway |
| 3.4.17.23 | more |
ACE2 is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses. Soluble sACE2 acts as receptor binding SARS-CoV glycoprotein S pseudotyped FIV virus and blocks virus infection of target cells |
| 3.4.17.23 | more |
ACE2 is down-regulated and ACE is up-regulated in hypertensive nephropathy. Ang II, once released, can act to up-regulate ACE but down-regulate ACE2 via the AT1 receptor-mediated mechanism. Activation of the ERK1/2 and p38 MAP kinase pathway may represent a key mechanism by which Ang II down-regulates ACE2 |
