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EC Number
Natural Substrates
Commentary (Nat. Sub.)
amyloid beta-peptide(1-40) + H2O
cleavage at the Asp7-Ser9 bond. Compared with amyloid beta-peptide(1-40), aggregation and cytotoxic effects of the degradation products amyloid beta-peptide(1-7) and amyloid beta-peptide(8-40) are reduced ot virtually absent. The enzyme inhibits aggregation, deposition, and cytotoxicity of amyloid beta-peptide in vitro may affect susceptibility to Alzheimer‘s disease
amyloid beta-protein 1-40 + H2O
ACE cleaves amyloid beta-protein 1-40 between Asp7 and Ser8
amyloid beta-protein 1-42 + H2O
angiotensin-converting enzyme converts amyloid beta-protein 1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas.The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimer’s disease
amyloid beta-protein 1-42 + H2O
angiotensin-converting enzyme converts amyloid beta-protein1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas. The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimer’s disease
amyloid beta-protein 1-42 + H2O
ACE cleaves amyloid beta-protein 1-42 at multiple sites
angiotensin I + H2O
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angiotensin I + H2O
enzyme plays a major role in blood pressure regulation
angiotensin I + H2O
the enzyme plays an important role in blood pressure homeostasis
angiotensin I + H2O
angiotensin II is a vasoconstrictor that raises blood pressure and is formed from angiotensin I by the angiotensin I converting enzyme in the reninangiotensin system
angiotensin I + H2O
i.e. DRVYIHPFHL
Results 1 - 10 of 31 > >>