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EC Number
Natural Substrates
Commentary (Nat. Sub.)
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
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(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
substrate for epoxide hydrolase activity
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
substrate for the epoxide hydrolase reaction, in addition LTA4H shows a peptidase activity
leukotriene A4 + H2O
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leukotriene A4 + H2O
one of the physiologically important processes in the arachidonic acid biosynthetic pathway, leukotriene B4 is a proinflammatory mediator which stimulates adhesion of circulating neutrophils to vascular endothelium and directs their migration towards sites of inflammation
leukotriene A4 + H2O
central enzyme in leukotriene B4 formation, it is likely to be involved in transcellular leukotriene formation
leukotriene A4 + H2O
biosynthesis of leukotriene B4
leukotriene A4 + H2O
leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid
leukotriene A4 + H2O
leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid. LTB4 functions as a macrophage chemoattractant in the zebrafish, injection into the hindbrain ventricle of wild-type arvae induces rapid recruitment of macrophages
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possible proteolytic function of the enzyme may be limited to the extracellular space
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