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Results 1 - 9 of 9
EC Number
Natural Substrates
Commentary (Nat. Sub.)
(-)-cocaine + H2O
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6-monoacetylmorphine + H2O
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cocaine + H2O
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cocaine + H2O
CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine
cocaine + H2O
hCE-2 exhibits different drug ester substrate specificity from the human liver carboxylesterase hCE-1, which hydrolyzes the methyl ester of cocaine. hCE-2 may play an important role in the degradation of cocaine and heroin in human tissues
cocaine + H2O
Rhodococcus sp. MB1 is capable of utilizing cocaine as a sole source of carbon and nitrogen for growth. The organism lives in the rhizosphere soil of the tropane alkaloid-producing plant Erythroxylum coca. The cocaine esterase initiates degradation of cocaine, which is hydrolyzed to ecgonine methyl ester and benzoate. Both of these esterolytic products are further metabolized by Rhodococcus sp. strain MB1. This activity is inducible in Rhodococcus sp. strain MB1, since no cocaine esterase activity is observed in cells grown on 15 mM succinate as a sole source of carbon
cocaine + H2O
strain MB11L of Pseudomonas maltophilia is capable of using cocaine as its sole carbon and energy source
heroin + H2O
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more
heroin hydrolysis to 6-MAM and morphine is accelerated by cholinesterases, including acetylcholinesterase (AChE, EC 3.1.1.7) and/or butyrylcholinesterase (BChE, EC 3.1.1.8)
Results 1 - 9 of 9