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EC Number
Natural Substrates
Commentary (Nat. Sub.)
1,2-dioleoylglycerol + H2O
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1-monooleoylglycerol + H2O
3times higher activity than with 2-oleoylglycerol
2-monooleoylglycerol + H2O
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cholesteryl ester + H2O
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cholesteryl oleate + H2O
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diacylglycerol + H2O
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dioleoylglycerol + H2O
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monoacylglycerol + H2O
-
more
expressed at a higher level in oxidative fibres than in glycolytic fibres. The two physiological stimuli adrenaline and contraction increase enzyme activity in muscle, and the effects are partially additive. Adrenaline acts via beta-adrenergic activation of cAMP-dependent protein kinase, while the effect of contractions is mediated by protein kinase C, at least partly via the extracellular signal-regulated kinase pathway. Endurance training diminishes the sensitivity of muscle hormone-sensitive lipase to adrenaline but increases the contraction-mediated activation
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hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis
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