EC Number |
Natural Substrates |
---|
2.8.1.4 | L-cysteine + 'activated' tRNA |
- |
2.8.1.4 | L-cysteine + 'activated' tRNA |
sulfur deficient tRNA is the natural substrate |
2.8.1.4 | L-cysteine + 'activated' tRNA |
enzyme is part of the sulfur-transferase system which forms 4-thiouridylate in tRNA |
2.8.1.4 | more |
Ctu1 (cytosolic tRNA thiouridilase) associates with the conserved Ctu2 protein and this complex is the wobble uridine-34 thiolase of cytosolic tRNAs in eukaryotes, 2-thiouridylation of tRNAs |
2.8.1.4 | more |
tRNA (LYS), but not the tRNA (MET), which has a C at position 34, is thiolated in vivo |
2.8.1.4 | sulfide + tRNA-uridine |
the enzyme is invoved in biosynthesis of 4-thiouridine in tRNA. 4-Thiouridine, is a modified nucleotide of tRNA that is conserved from bacteria to archaea, where it functions as a sensor for near-UV irradiation |