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EC Number
Natural Substrates
Commentary (Nat. Sub.)
ADP + ADP
facilitates transfer of high-energy phosphorylss and signal communication between mitochondria and actomyosin in cardiac muscle
ADP + ADP
provides unique buffering role against rapid concentration changes of any component of the adenylate pool
ADP + ADP
facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems
ADP + ADP
involved in energy metabolism
ADP + TDP
Escherichia coli adenylate kinase is able to synthesize TTP, but the activity is too low to explain the high rate of TTP accumulation uring amino acid starvation of cells
ATP + AMP
-
more
adenylate kinase activity Is required for Mre11/Rad50-mediated DNA tethering
more
adenylate kinase is involved in the control of the rate of glycolysis
more
adenylate kinase participates in the regulation of ADP-dependent endocytosis of high-density lipoprotein by consuming the ADP generated by the ecto-F1-ATPase
more
adenylate kinase activity of the Mre11/Rad50 complex, which is part of a DNA repair complex, promotes DNA-DNA associations
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