EC Number   |
Natural Substrates  |
|---|
   2.7.11.18 | ATP + light chain myosin II |
- |
| 2.7.11.18 | ATP + light chain myosin II |
cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos |
| 2.7.11.18 | ATP + light chain myosin II |
causes endothelial contraction |
| 2.7.11.18 | ATP + light chain myosin II |
cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease |
| 2.7.11.18 | ATP + light chain myosin II |
MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview |
| 2.7.11.18 | ATP + light chain myosin II |
MLCK plays a key role in the control of MLC-phosphorylation status, and it modulates barrier function through its regulation of intracellular contractile machinery, overview, endothelial mechanism of MLC-dependent barrier injury in burns, overview |
| 2.7.11.18 | ATP + light chain myosin II |
myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events |
| 2.7.11.18 | ATP + light chain myosin II |
regulatory myosin chain, in thick filaments, isozyme L-MLCK plays a role in cytoskeleton organization |
| 2.7.11.18 | ATP + light chain myosin II |
roles of MLCK and ROCK on myosin II activation, overview, a global, MLCK-dependent increase in myosin II cortical contractility accompanies the metaphase-anaphase transition in sea urchin eggs, overview |
| 2.7.11.18 | ATP + light chain myosin II |
the enzyme is important in regulation of shape, adhesion and migration of fibrosarcoma cells, overview |
