EC Number   |
Natural Substrates  |
|---|
   2.4.1.65 | GDP-beta-L-fucose + asialofetuin |
- |
| 2.4.1.65 | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R |
- |
| 2.4.1.65 | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R |
isoform Fut3 predominantly exhibits alpha1-4 fucosyltransferase activity |
| 2.4.1.65 | GDP-beta-L-fucose + NeuAcalpha2-3Galbeta1-4Glc-NAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta1-ceramide |
the enzyme catalyzes the fucose transfer from GDP-fucose to GlcNAc residues of the sialylated polylactosamine acceptor leading to two isomeric monofucosyl antigens, VIM2 and sialyl-Lex |
| 2.4.1.65 | GDP-fucose + Gal-beta-1,4GlcNAc-beta-1-R |
- |
| 2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
the enzyme catalyzes the synthesis of fucosylated Lewis motifs that are associated with cell-adhesion events and are differentially expressed during cell differentiation |
| 2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
inactivation of the enzyme eliminates expression of all Lewis antigens |
| 2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme |
| 2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
the enzyme may catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in expression of sialyl Lewis X and Lewis X/SSEA-1 antigens. It may be involved in blood group Lewis determination |
| 2.4.1.65 | GDP-L-fucose + Lewis antigen |
on the cell surface of hepatocarcinoma cells H7721 |
