EC Number   |
Natural Substrates |
|---|
   2.4.1.65 | GDP-beta-L-fucose + asialofetuin |
- |
| 2.4.1.65 | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R |
- |
| 2.4.1.65 | GDP-fucose + Gal-beta-1,4GlcNAc-beta-1-R |
- |
| 2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
inactivation of the enzyme eliminates expression of all Lewis antigens |
| 2.4.1.65 | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R |
isoform Fut3 predominantly exhibits alpha1-4 fucosyltransferase activity |
| 2.4.1.65 | GDP-L-fucose + Lewis antigen |
on the cell surface of hepatocarcinoma cells H7721 |
| 2.4.1.65 | GDP-beta-L-fucose + NeuAcalpha2-3Galbeta1-4Glc-NAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta1-ceramide |
the enzyme catalyzes the fucose transfer from GDP-fucose to GlcNAc residues of the sialylated polylactosamine acceptor leading to two isomeric monofucosyl antigens, VIM2 and sialyl-Lex |
| 2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
the enzyme catalyzes the synthesis of fucosylated Lewis motifs that are associated with cell-adhesion events and are differentially expressed during cell differentiation |
| 2.4.1.65 | more |
the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates |
| 2.4.1.65 | more |
the enzyme is involved in the biosynthesis of the sialyl Lewis x, i.e. Lex, epitope on leukocytes, which has been identified as an important component of leukocyte ligands for E- and P-selectin |
