EC Number |
Natural Substrates |
---|
1.8.4.13 | sulindac + NADPH |
activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr |
1.8.4.13 | L-methionine (S)-sulfoxide + NADPH + H+ |
membrane-bound enzyme form Mem-R,S-Msr |
1.8.4.13 | more |
methionine sulfoxide reduction pathway, overview |
1.8.4.13 | more |
possible pathway, overview |
1.8.4.13 | L-(-)-methionine S-oxide + NADPH |
the enzyme is specific for the L-(-)-stereoisomer |
1.8.4.13 | more |
the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues |
1.8.4.13 | more |
the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions |