EC Number |
Natural Substrates |
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3.5.3.1 | more |
mitochondrial isoform arginase II negatively regulates NO synthase 1 activity by limiting substrate availability in its microdomain |
3.5.3.1 | more |
presence of arginine pools, which are accessible to NO synthase and enzyme, but not exchangeable |
3.5.3.1 | more |
the wild type enzyme does not hydrolyze 1-amino-4-guanidinobutane (agmatine) |
3.5.3.1 | more |
arginase II is constitutively expressed in the airways of normal mice, whereas arginase I is undetectable in normal airways, while its expression is increased in airways of mice exposed to ovalbumin |
3.5.3.1 | more |
complex regulation of natural killer cell functions by arginine availability |
3.5.3.1 | more |
hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia |
3.5.3.1 | more |
infection of mice with Schistosoma mansoni cercariae elevates arginase activity |
3.5.3.1 | more |
recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors |