EC Number   |
Natural Substrates |
|---|
   3.4.24.71 | big endothelin-1 + H2O |
key enzyme in the biosynthesis of the endothelins |
| 3.4.24.71 | big endothelin-1 + H2O |
ECE-1 is a critical enzyme in the production of the potent vasoconstrictor peptide endothelin, ET-1 |
| 3.4.24.71 | big endothelin-1 + H2O |
- |
| 3.4.24.71 | big endothelin-1 + H2O |
final step of posttranslational processing of this peptide |
| 3.4.24.71 | big endothelin-1 + H2O |
most potent naturally occurring vasoconstrictor |
| 3.4.24.71 | big endothelin-1 + H2O |
activation |
| 3.4.24.71 | big endothelin-1 + H2O |
ECE-1 inhibition in MCF-7 breast cancer cells leads to a significantly decreased ET-1 expression and reduced cell invasiveness, overview |
| 3.4.24.71 | big endothelin-1 + H2O |
short-term endothelin-1 release is not involved in the isometric tension in response to different agonists, e.g. 15-E2t-IsoP, of human umbilical vein ring with or without endothelium, overview |
| 3.4.24.71 | big endothelin-1 + H2O |
big endothelin-1 is hydrolyzed at Asp18-Ile19 |
| 3.4.24.71 | big endothelin-3 + H2O |
specific for this substrate, big-endothelin-1 is no substrate |
