EC Number   |
Natural Substrates  |
|---|
   3.4.21.92 | more |
ClpP linked to many activities, including sporulation, cell competence, stress tolerance and regulation of gene expression |
| 3.4.21.92 | more |
removing of irreversibly damaged polypeptides |
| 3.4.21.92 | more |
enzyme complex ClpPRS consisting of five ClpP protease molecules, four nonproteolytic ClpR molecules, and two associated ClpS molecules, is central to chloroplast biogenesis, thylakoid protein homeostasis, and plant development |
| 3.4.21.92 | more |
enzyme is required for release of autolysin A and pneumolysin. In vivo, it is required for growth of pneumococcus in the lungs and blood in a murine model of disease |
| 3.4.21.92 | more |
enzyme is required for the growth at elevated temperature and for virulence |
| 3.4.21.92 | more |
stress- and starvation-induced bulk protein turnover depends virtually exclusively on enzyme, which is also essential for intracellular protein quality control |
| 3.4.21.92 | more |
ClpP associates with ClpX or ClpA to form the AAA+ ClpXP or ClpAP proteases |
| 3.4.21.92 | more |
ClpP binds to AAA+ ATPase/unfoldase, ClpA or ClpX |
| 3.4.21.92 | more |
ClpP requires association with ClpA or ClpX to unfold and thread protein substrates through the axial pore into the inner chamber where degradation occurs |
| 3.4.21.92 | Starvation proteins + H2O |
the ClpP proteolytic subunit plays a subtle but important role when cells are recovering from starvation. This enzyme is important in the selective degradation of starvation proteins when growth resumes |
