EC Number |
Natural Substrates |
---|
3.4.17.23 | more |
ACE2 plays a crucial role in liver fibrogenesis |
3.4.17.23 | more |
ACE2 plays a key role in pulmonary, cardiovascular and hypertensive and diabetic kidney diseases. ACE2 plays a pivotal role in maintaining a balanced status of the RAS synergistically with ACE by exerting counter-regulatory effects |
3.4.17.23 | more |
ACE2 plays a pivotal role in the central regulation of blood pressure and volume homeostasis |
3.4.17.23 | more |
ACE2 plays a protective role in organs directly related to hypertension and associated diseases |
3.4.17.23 | more |
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited |
3.4.17.23 | more |
ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue |
3.4.17.23 | more |
ACE2 is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses. Soluble sACE2 acts as receptor binding SARS-CoV glycoprotein S pseudotyped FIV virus and blocks virus infection of target cells |
3.4.17.23 | more |
a combination of ACE2 and ACE convert amyloid-beta protein 43 to amyloid-beta protein 40 |
3.4.17.23 | QRPRLSHKGPMPF + H2O |
i.e. apein(1-13) |
3.4.17.23 | YGGFLRRIRPKLK + H2O |
i.e. dynorphin A 1-13 |