EC Number   |
Natural Substrates  |
|---|
   3.4.15.1 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O |
i.e. substance P, lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5) |
| 3.4.15.1 | bradykinin + H2O |
- |
| 3.4.15.1 | bradykinin + H2O |
degradation |
| 3.4.15.1 | bradykinin + H2O |
inactivation |
| 3.4.15.1 | bradykinin + H2O |
bradykinin is a nonapeptide released from high molecular weight kininogen, it exerts its vasodilatory effect mainly by stimulation of B2 receptors |
| 3.4.15.1 | more |
- |
| 3.4.15.1 | more |
potential role of follicular enzyme in early stages of follicular maturation and atresia |
| 3.4.15.1 | more |
the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes |
| 3.4.15.1 | more |
primary enzyme that is involved in the degradation of Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu in brain |
| 3.4.15.1 | more |
may contribute to elevated blood pressure in hypertensive disease via conversion of angiotensin I to angiotensin II or inactivation of bradykinin |
