EC Number   |
Natural Substrates |
|---|
   3.3.2.9 | cis-stilbene oxide + H2O |
- |
| 3.3.2.9 | epoxyestratrienol + H2O |
- |
| 3.3.2.9 | juvenile hormone III + H2O |
poor substrate |
| 3.3.2.9 | more |
- |
| 3.3.2.9 | more |
enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation |
| 3.3.2.9 | more |
the enzyme may play a significant role in the secondary metabolism of juvenile hormone acid generated by juvenile hormone esterase |
| 3.3.2.9 | more |
the enzyme plays an important role in the metabolism of various xenobiotic compounds including the polycyclic aromatic hydrocarbon carcinogens. It is specifically involved in the formation of the ultimate carcinogen of benzopyrene |
| 3.3.2.9 | more |
induced about threefold by 5 mM phenobarbital |
| 3.3.2.9 | more |
involved in the biotransformation of epoxides produced from either xeno- or endobiotics. The diols produced are generally detoxification products but in several instances, such as 9,10-epoxybenzopyrene-7,8-diol, they are very potent mutagens and possible carcinogens. The enzyme is induced by phenobarbital |
| 3.3.2.9 | more |
the enzyme is expected to play a purely protective role with respect to epoxides metabolically produced from pharmaceutical drugs |
