EC Number |
Natural Substrates |
---|
3.1.1.79 | more |
hormone-sensitive lipase may be the rate-limiting enzyme controlling the cellular catabolism of diacylglycerol in adipose tissue and that of cholesteryl esters in macrophage foam cells and steroidogenic tissues releasing the cholesterol required for adrenal steroidogenesis |
3.1.1.79 | more |
in the skeletal muscle at rest there is a high constitutive level of hormone-sensitive lipase activity, which is not a function of biopsy freezing. The combination of low adrenaline and Ca2+ levels and resting levels of insulin appears to dictate the levels of activity of hormone-sensitive lipase at rest. During the onset of low and moderate aerobic exercise enzyme activity is activated by contractions, in the apparent absence of increases in circulating adrenaline. However, adrenaline may contribute to the early activation of the enzyme during intense aerobic exercise. The contraction-induced activation appears to be related to the increase in protein kinase C and extracellular signal regulated kinase activity associated with Ca2+ and/or other unknown activators. As low- and moderate-intensity exercise continues beyond a few min, activation by adrenaline through the cAMP cascade and protein kinase A also appears to occur. With prolonged moderate-intensity exercise beyond 12 h and sustained high-intensity exercise, HSL activity decreases despite continuing increases in adrenaline, possibly as a result of increasing accumulation of free AMP, activation of AMP-activated kinase and phosphorylation of inhibitory sites on the hormone-sensitive lipase. Intramuscular factors dominate the control of hormone-sensitive lipase activity, with hormonal factors playing a smaller role |
3.1.1.79 | more |
key enzyme in fatty acid mobilization |
3.1.1.79 | more |
rate-limiting enzyme in lipolysis |
3.1.1.79 | more |
the enzyme catalyses the hydrolysis of myocellular triacylglycerol, which is a potential energy source diuring exercise |
3.1.1.79 | more |
the enzyme is involved in the hormone regulated release of fatty acids and glycerol from adipocyte lipid stores |
3.1.1.79 | more |
hormone-sensitive lipase is a key enzyme of acylglycerol metabolism in white adipose tissue. The hormone-sensitive lipase activity in white adipose tissue is important for metabolic plasticity and inflammation. Hormone-sensitive lipase-mediated lipolysis and subsequent downstream free fatty acid signaling are important components of adipose tissue remodeling following acute and chronic beta3-adrenergic receptor activation |
3.1.1.79 | more |
LIPY may be responsible for the utilization of stored triglycerides during dormancy and reactivation of the pathogen Mycobacterium tuberculosis |
3.1.1.79 | more |
the enzyme a substrate preference for the diacylglycerols originating from triacylglycerols. The ee% of 1,2-sn-diolein over 2,3-sn-diolein increases with the level of hydrolysis indicated that HSL has a preference for 2,3-sn-diolein as a substrate and therefore a stereopreference for the sn-3 position of dioleoylglycerol. The ee% of 1,2-sn-diolein reaches a maximum value of 36% at 42% hydrolysis |
3.1.1.79 | more |
sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol |