EC Number   |
Natural Substrates |
|---|
    2.7.4.14 | ATP + dCMP |
higher activity with the D-enantiomer compared to the L-enantiomer |
| 2.7.4.14 | ATP + dUMP |
- |
| 2.7.4.14 | ATP + dUMP |
higher activity with the D-enantiomer compared to the L-enantiomer |
| 2.7.4.14 | ATP + gemcitabine |
i.e. 2',2'-difluorodeoxycytidine |
| 2.7.4.14 | ATP + UMP |
- |
| 2.7.4.14 | ATP + UMP |
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis |
| 2.7.4.14 | ATP + UMP |
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies |
| 2.7.4.14 | more |
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview |
| 2.7.4.14 | more |
UMP-CMPK2 may have other functions in addition to the supply of substrates for mtDNA synthesis, it is highly expressed in leukemia cells, in bone marrow, and is tightly correlated with macrophage activation and inflammatory response |
| 2.7.4.14 | more |
hyperensitivity and resistance against anti-cancer drugs in the different cervical tumour cell lines, effects of changes on UMP/CMPK1 expression on CTP and UTP synthesis , overview |
