EC Number   |
Natural Substrates |
|---|
   2.7.11.18 | more |
the enzyme plays an important role in TNFalpha-dependent induction of NFkappaB activity, mechanism |
| 2.7.11.18 | ATP + myosin light chain |
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics |
| 2.7.11.18 | ATP + [myosin light chain] |
the multifunctional regulatory enzyme stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain, kinetics, overview |
| 2.7.11.18 | more |
the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview |
| 2.7.11.18 | ATP + [myosin light chain] |
the non-muscle myosin light chain kinase is involved in regulation of hepatic functions in response to intra- and extracellular signals |
| 2.7.11.18 | more |
ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview |
