EC Number   |
Natural Substrates |
|---|
   2.7.11.18 | more |
the enzyme is a key regulator of various forms of cell motility involving actin and myosin II |
| 2.7.11.18 | more |
the enzyme is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons, overview |
| 2.7.11.18 | more |
the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview |
| 2.7.11.18 | more |
the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview |
| 2.7.11.18 | more |
ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview |
| 2.7.11.18 | more |
actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview |
| 2.7.11.18 | more |
actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview. MLCK phosphorylated at Ser828 stimulates the ATPase activity of unphosphorylated myosin more effectively than the control MLCK |
| 2.7.11.18 | more |
cytochalasin-induced increases in paracellular permeability are also mediated by MLC in Caco-2 monolayers |
| 2.7.11.18 | more |
MLCK is a substrate of AMP-activated protein kinase, AMPK |
| 2.7.11.18 | more |
myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice, overview |
