EC Number   |
Natural Substrates  |
|---|
   2.3.1.48 | histone + acetyl-CoA |
- |
| 2.3.1.48 | histone + acetyl-CoA |
histone acetylation is an important posttranslational modification correlated with gene activation, the HAC1 is involved in the regulation of flowering time via repression of flowering locus C, the enzyme participates in many physiological processes, including proliferation, differentiation, and apoptosis |
| 2.3.1.48 | histone + acetyl-CoA |
key enzyme in post-translational modification of histones associated with transcriptionally active genes |
| 2.3.1.48 | histone + acetyl-CoA |
phosphorylation of p300 at Ser1834 by the kinase Akt is essential for its histone acetyltransferase and transcriptional activity |
| 2.3.1.48 | histone H3 + acetyl-CoA |
- |
| 2.3.1.48 | histone H3 + acetyl-CoA |
regulation |
| 2.3.1.48 | histone H3 + acetyl-CoA |
acetylation of Lys9, and Lys14 |
| 2.3.1.48 | histone H3 + acetyl-CoA |
the enzyme is involved in ethanol-induced acetylation of histone H3 in hepatocytes, potential mechanism for gene expression activation by the enzyme, overview |
| 2.3.1.48 | histone H4 + acetyl-CoA |
- |
| 2.3.1.48 | histone H4 + acetyl-CoA |
acetylation of Lys5, Lys8, and Lys12, Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation |
