EC Number   |
Natural Substrates |
|---|
   2.3.1.48 | acetyl-CoA + histone |
histone acetylation on Lys16 by Sas2 |
| 2.3.1.48 | acetyl-CoA + histone H |
histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway |
| 2.3.1.48 | acetyl-CoA + histone |
histone H1 is not acetylated in vivo |
| 2.3.1.48 | acetyl-CoA + histone |
histone H3 is the preferred substrate |
| 2.3.1.48 | more |
histones H3 and H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, are associated with Hat1 in the cytosol of chicken cells. Hat1 regulates integrity of cytosolic histone H3-H4 containing complex, effect of Hat1 on status for the cytosolic histones H3/H4 pre-deposition complexes with respective chaperone proteins, overview |
| 2.3.1.48 | acetyl-CoA + histone |
important role of the enzyme for chromatin modulating activity |
| 2.3.1.48 | more |
in addition to Asf1, Rtt109 is also functionally linked to Rtt101, Mms1, and Mms22 |
| 2.3.1.48 | more |
in response to DNA damage, Tip60 acetylates ATM, a DNA damage related kinase, allowing for phosphorylation of Chk2 and p53 by ATM. HATs perform a conserved mechanism of acetyl-transfer, where the lysine-containing substrate directly attacks enzyme-bound acetyl-CoA. The ability of HATs to form distinct multi-subunit complexes provide a means to regulate HAT activity by altering substrate specificity, targeting to specific loci, enhancing acetyltransferase activity, restricting access of non-target proteins, and coordinating the multiple enzyme activities of the complex |
| 2.3.1.48 | more |
increase in eNOS mRNA, caused by shear stress, is completely blocked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering RNA |
| 2.3.1.48 | acetyl-CoA + histone |
involved in chromatin remodeling and DNA repair |
