EC Number   |
Natural Substrates |
|---|
   2.3.1.286 | NAD+ + [glutamate oxaloacetate transaminase 2]-N6-acetyl-L-lysine |
isoform SIRT3 is the major deacetylase of glutamate oxaloacetate transaminase 2 |
| 2.3.1.286 | NAD+ + [heat shock protein 10]-N6-acetyl-L-lysine56 |
- |
| 2.3.1.286 | NAD+ + [histone H4]-N6-acetyl-L-lysine16 |
the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin |
| 2.3.1.286 | NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine |
Sirt3 can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that promotes regeneration of antioxidants and catalyzes a key regulation point of the citric acid cycle |
| 2.3.1.286 | NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine413 |
acetylation of Lys413 decreases catalysis and SIRT3 reactivates isocitrate dehydrogenase 2 upon deacetylation |
| 2.3.1.286 | NAD+ + [nuclear receptor LXR]-N6-acetyl-L-lysine |
SIRT1 positively regulates liver X receptors (LXRs) by deacetylation at lysine. Deacetylation of liver X receptors (LXRs) by SIRT1 may be a mechanism that affects atherosclerosis and other agingassociated diseases |
| 2.3.1.286 | NAD+ + [p53 protein]-N6-acetyl-L-lysine |
SIRT1 deacetylase is a negative regulator of p53 function capable of modulating cellular senescence |
| 2.3.1.286 | NAD+ + [p53 protein]-N6-acetyl-L-lysine382 |
Sir2 is involved in the regulation of p53 function via deacetylation |
| 2.3.1.286 | NAD+ + [PER2 protein]-N6-acetyl-L-lysine |
SIRT1 regulates circadian clock gene expression through PER2 deacetylation |
| 2.3.1.286 | NAD+ + [protein]-N6-acetyl-L-lysine |
- |
