EC Number   |
Natural Substrates |
|---|
    1.14.19.1 | more |
due to a population-based, longitudinal cohort study of men, the risk of fracture is highest among men with the highest levels of SCD activity index, overview |
| 1.14.19.1 | more |
inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview |
| 1.14.19.1 | more |
role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview |
| 1.14.19.1 | more |
heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate |
| 1.14.19.1 | more |
enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center |
| 1.14.19.1 | more |
in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O |
| 1.14.19.1 | more |
mouse SCD3 isoform preferentially catalyzes palmitoleate synthesis |
| 1.14.19.1 | more |
SCD1 catalyses the DELTA9 desaturation of 12-19 carbon saturated fatty acids to monounsaturated fatty acids |
| 1.14.19.1 | palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ |
- |
| 1.14.19.1 | palmitoyl-CoA + AH2 + O2 |
- |
