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Results 11 - 18 of 18

EC Number	Natural Substrates	Commentary (Nat. Sub.)
1.1.1.81	hydroxypyruvate + NADPH	-
1.1.1.81	hydroxypyruvate + NADPH + H+	-
1.1.1.81	hydroxypyruvate + NADPH + H+	key enzyme of the serine cycle
1.1.1.81	more	enzyme deficiency leads to primary hyperoxaluria type 2 with increased urinary oxalate levels, formation of kidney stones, and renal failure
1.1.1.81	more	the enzyme is transcriptionally regulated by the peroxisome proliferator-activated receptor alpha, PPARalpha, in liver, overview
1.1.1.81	more	HPR3 prefers NADPH over NADH and converts glycerate to hydroxypyruvate, the purified recombinant HPR3 shows similar activity with hydroxypyruvate and glyoxylate
1.1.1.81	more	the recombinant AtHPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate
1.1.1.81	more	the recombinant AtHPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly

Results 11 - 18 of 18

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Release 2023.1 (January 2023)