EC Number   |
Natural Substrates |
|---|
   2.4.1.90 | UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides |
main enzyme responsible for the transfer of galactose residues from UDPgalactose into terminal N-acetylglucosamine residues of complex-type oligosaccharides in newly synthesized glycoproteins in the Golgi apparatus. Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId, a severe neurologic disease characterized by a hydrocephalus, myopathy and blood-clotting defects |
| 2.4.1.90 | UDP-galactose + N-acetyl-D-glucosamine |
synthesis of Galbeta1,4GlcNAc groups in N-linked sugar chains of glycoproteins involved in many physiological functions, e.g. sperm-egg interactions, cell migration, and embryonic development, enzyme expression is highly increased during cycloheximide-induced cell apoptosis in liver carcinoma |
| 2.4.1.90 | UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides |
the enzyme facilitates sperm binding to the oocyte zona pellucida |
| 2.4.1.90 | more |
the enzyme is involved in regulation of carbohydrate composition of milk during lactation, endocrine enzyme regulation, overview |
| 2.4.1.90 | UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides |
the enzyme is involved in the biosynthesis of a variety of carbohydrate structures in glycoproteins and glycolipids |
| 2.4.1.90 | more |
the enzyme is one of the key molecules on the sperm surface, and is likely to be involved in binding to the egg coat, the zona pelludica, to mediate sperm-egg interaction |
| 2.4.1.90 | more |
the enzyme is part of the endoplasmic reticulum and Golgi glycosylation network, glycosyltransferase metabolism, overview |
| 2.4.1.90 | UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides |
the enzyme may be involved in the synthesis of plasma glycoproteins by the liver during secretion, and may possibly be required for secretion of these proteins |
| 2.4.1.90 | UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides |
the enzyme may be involved in the synthesis of poly-N-acetyllactosamine, lacto-N-neotetraose and probably lacto-N-neotetraosylceramide in addition to the formation of the Galbeta1-4GlcNAc group of glycoprotein sugar chains and lactose |
| 2.4.1.90 | more |
the enzyme utilizes different glycoproteins and glycolipids as substrates, patients with rheumatoid arthritis have a higher content of an acidic isoform compared to healthy individuals, the isoform is not associated with inflammation per se but specifically with rheumatoid arthritis |
