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EC Number
Natural Substrates
Commentary (Nat. Sub.)
Tip60 is part of the evolutionarily conserved NuA4 complex
Tip60, in complex with homologues of the mammalian Tip60 complex, exhibits functional redundancy with two other groups of genes, known as synthetic multivulva A and B genes, synMUV. Therefore, the genes encoding proteins of the Tip60 complex are termed class C synMUV genes. SynMUV A and B counteract EGF to Ras to MAPK signaling and the Tip60 complex is a chromatin-modifying complex
isoform GCN5 is not the enzyme responsible for histone acetylation at cold-regulated genes COR promoters during cold acclimation
Brahma is a target of enzyme Kat6B
enzyme GCN5b interacts with AP2-domain proteins, apicomplexan plant-like transcription factors, as well as a core complex that includes the co-activator ADA2-A, TFIID subunits, LEO1 polymerase-associated factor (Paf1) subunit, and RRM proteins
enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300
GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters
GCN5 directly targets HSFA3 and UVH6 and affects their H3K9 and H3K14 acetylation levels
piccoloNuA4 peptide + acetyl-CoA
the peptide is part of the physiologic enzme complex, overview
promyelotic leukemia zinc finger gene + acetyl-CoA
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