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EC Number
Natural Substrates
Commentary (Nat. Sub.)
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Tip60 is part of the evolutionarily conserved NuA4 complex
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Tip60, in complex with homologues of the mammalian Tip60 complex, exhibits functional redundancy with two other groups of genes, known as synthetic multivulva A and B genes, synMUV. Therefore, the genes encoding proteins of the Tip60 complex are termed class C synMUV genes. SynMUV A and B counteract EGF to Ras to MAPK signaling and the Tip60 complex is a chromatin-modifying complex
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isoform GCN5 is not the enzyme responsible for histone acetylation at cold-regulated genes COR promoters during cold acclimation
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Brahma is a target of enzyme Kat6B
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enzyme GCN5b interacts with AP2-domain proteins, apicomplexan plant-like transcription factors, as well as a core complex that includes the co-activator ADA2-A, TFIID subunits, LEO1 polymerase-associated factor (Paf1) subunit, and RRM proteins
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enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300
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GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters
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GCN5 directly targets HSFA3 and UVH6 and affects their H3K9 and H3K14 acetylation levels
piccoloNuA4 peptide + acetyl-CoA
the peptide is part of the physiologic enzme complex, overview
promyelotic leukemia zinc finger gene + acetyl-CoA
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