EC Number   |
Metals/Ions |
Reference |
|---|
   7.2.2.10 | Ba2+ |
PMCA of neurons is electroneutral and exchanges 2 H+ for each Ca2+ or Ba2+ ion extruded |
699788 |
| 7.2.2.10 | Ca2+ |
- |
667650, 667995, 668626, 669402, 670669, 670677, 720644 |
| 7.2.2.10 | Ca2+ |
0.1 mM used in assay conditions |
749980 |
| 7.2.2.10 | Ca2+ |
activates at 0.001 mM |
210478 |
| 7.2.2.10 | Ca2+ |
binding involves Glu309 which acts as a gating residue for cytoplasmic Ca2+ to reach the binding cavity, Ca2+ binding site structure and mechanism |
670677 |
| 7.2.2.10 | Ca2+ |
binding structure and kinetics in the crystallized enzyme-phospholamban complex, overview |
667996 |
| 7.2.2.10 | Ca2+ |
calcium occupancy of site I is required to trigger cooperative binding to site II and catalytic activation |
712744 |
| 7.2.2.10 | Ca2+ |
dependent on |
670757, 695512, 695863, 695867, 695986, 696294, 696744, 697151, 697160, 697167, 697168, 697629, 697858, 697976, 698270, 698857, 698885, 699293, 700250, 700293, 700805, 700969, 701104, 701312, 719980 |
| 7.2.2.10 | Ca2+ |
dependent on, at very low Ca2+ concentrations the PMCA is nearly inactive, unstimulated PMCA pumps have poor affinity for Ca2+ |
695858 |
| 7.2.2.10 | Ca2+ |
dependent on, but at high Ca2+ concentrations no significant increase in enzyme activity is observed |
734224 |
