EC Number   |
Metals/Ions |
Reference |
|---|
   5.6.1.6 | Ca2+ |
stimulates |
675622 |
| 5.6.1.6 | Cd2+ |
coordinated by residues G551, S549, and L548. Highly activating the chloride channel activity of CFTR mutant G551D in absence of ATP, but not of wild-type CFTR or mutant G551A |
699294 |
| 5.6.1.6 | Co2+ |
best divalent metal activator |
654515 |
| 5.6.1.6 | K+ |
activates CFTR in myocytes |
675622 |
| 5.6.1.6 | Mg2+ |
- |
675176, 698823, 699787, 700296, 700618 |
| 5.6.1.6 | Mg2+ |
1.5 mM used in assay conditions |
749957 |
| 5.6.1.6 | Mg2+ |
activates |
654515 |
| 5.6.1.6 | Mg2+ |
dependent on |
696099, 697846 |
| 5.6.1.6 | Mg2+ |
needed for ATP hydrolysis |
676761 |
| 5.6.1.6 | Mg2+ |
required |
698868, 734231, 734305, 734398, 734545, 751114 |
