EC Number |
Metals/Ions |
Reference |
---|
4.2.1.28 | Ca2+ |
1.6-1.9 mol/mol of enzyme. CaCl2 and substrate show not only a stabilizing effect but also some activating effect of about 30% |
714211 |
4.2.1.28 | Ca2+ |
directly coordinates to substrate and is essential for structural retention and substrate binding |
715171 |
4.2.1.28 | Co2+ |
in the cob(II)alamin cofactor |
696252 |
4.2.1.28 | Co2+ |
in the cobalamin cofactor |
698752 |
4.2.1.28 | Co2+ |
in the cobalamin cofactor, presence of a positive charge at the beta135 residue increases the affinity for cobalamins but is not essential for catalysis, and the introduction of a negative charge there prevents the enzyme-cobalamin interaction |
697886 |
4.2.1.28 | Co2+ |
the is dependent on coenzyme B12, adenosylcobalamin |
698651 |
4.2.1.28 | Cr2+ |
0.10 mol/mol of enzyme |
714211 |
4.2.1.28 | Cs+ |
- |
5623 |
4.2.1.28 | Cs+ |
activates, Km: 5.0 mM |
5623 |
4.2.1.28 | Cs+ |
slight activation |
5627 |