EC Number   |
Metals/Ions |
Reference |
|---|
   3.4.24.B10 | Ca2+ |
- |
678344 |
| 3.4.24.B10 | Ca2+ |
can substitute for Zn2+ |
652002 |
| 3.4.24.B10 | Cu2+ |
activates, dependent on, multistep activation mechanism involving both furin cleavage and copper binding |
651290 |
| 3.4.24.B10 | Mg2+ |
marginal stimulatory effect |
678344 |
| 3.4.24.B10 | more |
metalloprotease |
652137 |
| 3.4.24.B10 | more |
metalloprotease domain is not essential for inhibition of cell cycle progression by the enzyme |
653221 |
| 3.4.24.B10 | Zn2+ |
activates, dependent on, enzyme contains a catalytically active zinc-binding domain |
651290 |
| 3.4.24.B10 | Zn2+ |
addition of ZnCl2 at concentrations below 0.05 mM increases the activity of ADAM12-S by approximately 30% |
678344 |
| 3.4.24.B10 | Zn2+ |
contains zinc |
734873 |
| 3.4.24.B10 | Zn2+ |
highly conserved zinc-binding motif HEXXHXXGXXH, the metalloprotease domain is the catalytically active site, the Met-turn is essential for the structural integrity of the zinc-binding site, Glu351 is essential for activity |
651886 |
