EC Number   |
Metals/Ions |
Reference |
|---|
   3.4.24.64 | Co2+ |
activation |
31398 |
| 3.4.24.64 | Co2+ |
activation of chelator-inactivated enzyme |
31383, 31385 |
| 3.4.24.64 | Co2+ |
divalent cation required for enzyme activity |
651890 |
| 3.4.24.64 | Co2+ |
metalloprotease |
31383, 31385, 31386, 31396, 31398 |
| 3.4.24.64 | Co2+ |
requirement |
31386 |
| 3.4.24.64 | Co2+ |
requirement (in vitro, in vivo not identified yet) |
31396 |
| 3.4.24.64 | Fe2+ |
divalent cation required for enzyme activity |
651890 |
| 3.4.24.64 | Fe2+ |
the N-terminus of MPP-processed frataxin shows a unique high-affinity iron site, and this iron center appears to mediate a self-cleavage reaction, the N-terminus blocks previously defined iron-binding sites located on the carboxylate-rich surface defined by the helix alpha1 and the beta-sheet beta1, most likely through electrostatic contact with the carboxylate-rich surface on the core protein, as well as inhibiting iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU, overview |
683686 |
| 3.4.24.64 | Mg2+ |
divalent cation required for enzyme activity |
651890 |
| 3.4.24.64 | Mn2+ |
activation |
31398 |
