EC Number   |
Metals/Ions |
Reference |
|---|
   3.4.24.17 | Ca2+ |
- |
708420, 709255 |
| 3.4.24.17 | Ca2+ |
Ca2+ is required to maintain the active conformation of the enzyme, full activity is detected at 1 mM Ca2+, at pH 7.5 and is retained at even higher concentrations of Ca2+, at lower concentrations the enzyme is autolyzed |
31017 |
| 3.4.24.17 | Ca2+ |
calcium-dependent |
651984 |
| 3.4.24.17 | Ca2+ |
calcium-dependent endopeptidase |
652709 |
| 3.4.24.17 | Ca2+ |
proenzyme contains 3 Ca2+ |
31017 |
| 3.4.24.17 | Ca2+ |
removal of Ca2+ from the enzyme solution results in a complete loss of activity that can be fully restored by addition of 1 mM Ca2+ |
31002 |
| 3.4.24.17 | Ca2+ |
required, the catalytic domains contain Ca2+ ions |
752877 |
| 3.4.24.17 | Co2+ |
addition of 0.5 mM Co2+ in the presence of Ca2+ restores activity of the apoenzyme, not by Co2+ alone |
31002 |
| 3.4.24.17 | Co2+ |
the active site zinc atom of stromelysin-1 is replaced by cobalt |
717283 |
| 3.4.24.17 | Mn2+ |
addition of 5 mM Mn2+ in the presence of Ca2+ restores activity of the apoenzyme, not by Mn2+ alone |
31002 |
