EC Number |
Metals/Ions |
Reference |
---|
2.7.6.5 | Iron |
structure shows an iron-binding site at the dimer interface |
761487 |
2.7.6.5 | Mg2+ |
essential for activation, the enzyme has a single Mg2+ binding site |
661439 |
2.7.6.5 | Mg2+ |
required |
737883, 738524, 738529 |
2.7.6.5 | Mg2+ |
required as a counter-ion for the nucleoside substrate, excess of Mg2+ is inhibitory |
642771 |
2.7.6.5 | Mg2+ |
required, binding structure analysis, overview |
739546 |
2.7.6.5 | Mg2+ |
the enzyme exploits a single Mg2+ ion to catalyze guanosine 3'-diphosphate 5'-triphosphate synthesis |
722545 |
2.7.6.5 | Mg2+ |
the magnesium concentration also affects the binding states of the tRNAs on the ribosome |
661712 |
2.7.6.5 | Mg2+ |
the optimal concentration for pppGpp synthesis is approximately equal to the total concentration of nucleotide substrates([ATP] + [GTP]) |
661218 |
2.7.6.5 | Mn2+ |
can partially replace Mg2+ in activation |
642771 |
2.7.6.5 | Mn2+ |
necessary cofactor at the hydrolase active site |
661439 |