EC Number |
Metals/Ions |
Reference |
---|
2.7.11.26 | Mg2+ |
- |
662124, 662127, 662134, 662152, 662261, 662284, 662302, 662313, 662388, 662674, 662686, 662688, 662690, 662855, 662870, 674847, 681536 |
2.7.11.26 | Mg2+ |
4 mM used in assay conditions |
762225 |
2.7.11.26 | Mg2+ |
binding site structure |
660602 |
2.7.11.26 | Mg2+ |
required |
739843, 739962, 740125, 740135, 740244, 740410, 740423, 740530, 740531, 740691, 740882, 741065, 741395, 741409, 741419, 741440, 760847 |
2.7.11.26 | Mn2+ |
- |
662870, 681536 |
2.7.11.26 | more |
no effect on enzyme activity with Na+ |
741440 |
2.7.11.26 | more |
not activated by K+, Ca2+ or Zn2+ |
681536 |
2.7.11.26 | Zn2+ |
high zinc concentrations (0.1-0.5 mM) increase glycogen synthase kinase-3beta phosphorylation on tyrosine 216, a phosphorylation associated with increased activity of this tau kinase, whereas the phosphorylation of GSK-3alpha at Y279 and the level of total GSK-3beta are not affected |
702438 |