EC Number   |
Metals/Ions |
Reference |
|---|
   2.7.11.17 | Ca2+ |
- |
663862, 664472, 664750, 665508, 666139, 672850, 674557, 702957, 703406, 705313, 705318, 705904 |
| 2.7.11.17 | Ca2+ |
4.42 mM stimulates activity |
692226 |
| 2.7.11.17 | Ca2+ |
a ubiquitous Ca2+-sensing protein called calmodulin (CaM), which contains four EF-hand Ca2+-binding motifs, undergoes conformational change upon Ca2+-binding, and the resulting Ca2+/CaM complex regulates a number of effector proteins including Ca2+/CaM-dependent protein kinases (Ca2+/CaMKs) |
739960 |
| 2.7.11.17 | Ca2+ |
absolutely dependent on |
664928 |
| 2.7.11.17 | Ca2+ |
activates |
491301 |
| 2.7.11.17 | Ca2+ |
activity becomes partially independent of Ca2+ after autophosphorylation |
491272 |
| 2.7.11.17 | Ca2+ |
after autophosphorylation, the enzyme is active in the absence of Ca2+/calmodulin and even in the presence of EGTA |
640689 |
| 2.7.11.17 | Ca2+ |
autophosphorylation of Ca2+/calmodulin-dependent protein kinase II converts the enzyme to a Ca2+-independent form, autophosphorylation site is Thr286 in the alpha subunit |
491234 |
| 2.7.11.17 | Ca2+ |
binding required for activity |
490796, 490797, 490800, 490801 |
| 2.7.11.17 | Ca2+ |
Ca2+/calmodulin-dependent |
395498, 491017, 491227, 491228, 491229, 491230, 491231, 491232, 491233, 491234, 491235, 491236, 491237, 491238, 491247, 491248, 491249, 491250, 491251, 491257, 491260, 491267, 491272, 491273, 491274, 491275, 491276, 491277, 491278, 491279, 491280, 491281, 491282, 491287, 491288, 491289, 491291, 491292, 491297, 491298, 491299, 491307 |
