EC Number |
Metals/Ions |
Reference |
---|
2.3.1.37 | Ca2+ |
optimal at concentration of 50 mM, inhibition above 200 mM |
486832 |
2.3.1.37 | Iron |
regulation of erythroid-specific isoform ALAS-2 via 5'-iron responsive element, i.e. IRE |
486853 |
2.3.1.37 | Li+ |
in Mg2+-containing medium: at 100 mM no effect on activity, higher concentrations are totally inhibitory |
486832, 486833 |
2.3.1.37 | Li+ |
optimal at 0.5 M, not inhibitory up to 1 M |
486832 |
2.3.1.37 | Mg2+ |
activates |
486809 |
2.3.1.37 | Mg2+ |
inhibition of complex form, stimulation of stripped form |
486837 |
2.3.1.37 | Mg2+ |
optimal at concentration of 50 mM, inhibition above 200 mM |
486832 |
2.3.1.37 | more |
partially purified enzyme requires high cation concentrations, equivalent to 0.3 M NaCl, for maximum activation, monovalent cations, i.e. Na+, K+, Li+, Rb+ or NH4+, in concentrations from 0.15 M to 0.30 M or divalent cations, i.e. Mg2+, Ca2+ or Mn2+, at lower concentrations of 0.03 M to 0.10 M are effective |
486812 |
2.3.1.37 | Na+ |
in Mg2+-containing medium: at 100 mM no effect on activity, higher concentrations are totally inhibitory |
486832, 486833 |
2.3.1.37 | Na+ |
inhibition of complex form, stimulation of stripped form |
486837 |