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EC Number Metals/Ions Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63Zinc in bacterial expression systems, recombinant hAGT is produced in increasingly larger quantities when growth media are supplemented with up to 0.1 mM ZnCl2. Metal-enriched hAGT samples have a 5fold increase in repair rate constant over conventionally purified protein samples and a 60fold increase over metal-stripped hAGT. Zinc confers a mechanistic enhancement to repair activity that does not result from an increase in substrate binding affinity. Zinc also provides conformational stability to hAGT that may influence its regulation 658014
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63Zn2+ Cys145 in hAGT exists as a reactive thiolate anion at neutral pH. The low pKa of Cys145 is dependent upon the bound Zn2+ 657947
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63Zn2+ N-terminal domain contains a bound zinc atom, and zinc binding confers a mechanistic enhancement to repair activity 671999
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