EC Number |
Metals/Ions |
Reference |
---|
1.14.16.4 | Ca2+ |
activates TPH2 promoter activity |
688507 |
1.14.16.4 | Ca2+ |
the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland |
688765 |
1.14.16.4 | Fe2+ |
- |
714213, 716436 |
1.14.16.4 | Fe2+ |
0.02 mM, 3.5fold increase in activity |
438662 |
1.14.16.4 | Fe2+ |
5fold increase in activity |
438658, 438661 |
1.14.16.4 | Fe2+ |
enzyme from pineal gland, stimulation |
438654 |
1.14.16.4 | Fe2+ |
Fe2+ concentration for half-maximal activation of recombinant N-terminal truncated enzyme: 0.0013 mM |
438676 |
1.14.16.4 | Fe2+ |
N- and C-terminal recombinant enzyme, iron is required for activity |
438672 |
1.14.16.4 | Fe2+ |
not required for full activity |
438664 |
1.14.16.4 | Fe2+ |
recombinant pineal enzyme contains 0.2-0.3 mol of iron/mol of enzyme |
438675 |