EC Number   |
Metals/Ions |
Reference |
|---|
    1.13.11.5 | Fe2+ |
- |
439392, 670622 |
| 1.13.11.5 | Fe2+ |
70% reduction of enzyme activity in crude extract in absence of Fe2+ and absolutely requirement for Fe2+ of the fusion protein of homogentisate dioxygenase and glutathione S-transferase, expressed in Escherichia coli |
439391 |
| 1.13.11.5 | Fe2+ |
contains a nonheme Fe2+ at the active site, that is coordinated near the interface between subunits in the HGO trimer by Glu-341, His-335 and His-371 |
439392 |
| 1.13.11.5 | Fe2+ |
contains Fe2+ |
742317 |
| 1.13.11.5 | Fe2+ |
contains non-porphyrin iron, valence change of enzymic iron during reaction: ferric and ferrous iron |
439382 |
| 1.13.11.5 | Fe2+ |
dependent on the presence of Fe2+ |
439389 |
| 1.13.11.5 | Fe2+ |
Fe2+ is an absolutely obligate cofactor and cannot be replaced by other divalent cations, highest enzyme activity in vitro at 2 mM Fe2+ |
439393 |
| 1.13.11.5 | Fe2+ |
Fe2+ is required as cofactor |
396333, 439380 |
| 1.13.11.5 | Fe2+ |
ferrous ion is required for maximal activity at pH 7 and pH 5.3 |
396333 |
| 1.13.11.5 | Fe2+ |
ferrous mercaptans at the active center |
396333 |
