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EC Number
Localization
Commentary
GeneOntology No.
Reference
7.2.2.8
apical plasma membrane
luminal acidification is required for the cell to redirect ATP7B to the apical domain and maintain it there under conditions of high Cu. Deacidification prevents Cu-directed delivery to apical domain
GO:0016324
AmiGO
QuickGO
735317
7.2.2.8
endosome
Cu2+ directs ATP7B to the apical domain of hepatic cells via basolateral endosomes
GO:0005768
AmiGO
QuickGO
735317
7.2.2.8
endosome
high Cu2+ concentration redistributes ATP7B to late endosomes or lysosomes that move along the axon in live hippocampal neurons
GO:0005768
AmiGO
QuickGO
734662
7.2.2.8
Golgi apparatus
-
GO:0005794
AmiGO
QuickGO
751286
7.2.2.8
Golgi apparatus
a second di-leucine motif in the carboxy tail of ATP7A (1459LL) is essential for steady-state localization in the trans-Golgi network by functioning in endosome-to-trans-Golgi network trafficking. Multiple di-leucine signals are required for recycling ATP7A from the plasma membrane to the trans-Golgi network
GO:0005794
AmiGO
QuickGO
751472
7.2.2.8
intracellular
-
GO:0005622
AmiGO
QuickGO
-
,
734718
7.2.2.8
intracellular
TgCuTP localizes to intraparasitic structures juxtaposed to the acidocalcisomes and/or plant-like vacuole
GO:0005622
AmiGO
QuickGO
734718
7.2.2.8
lysosome
high Cu2+ concentration redistributes ATP7B to late endosomes or lysosomes that move along the axon in live hippocampal neurons
GO:0005764
AmiGO
QuickGO
734662
7.2.2.8
membrane
-
GO:0016020
AmiGO
QuickGO
-
,
722821
,
725389
,
725999
,
733703
,
734282
7.2.2.8
membrane
an integral membrane protein of cytoplasmic membranes
GO:0016020
AmiGO
QuickGO
-
,
720396
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