EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   3.4.21.61 | cytoplasm |
epithelial cells, accumulates at the apical and basolateral sides of the cells |
GO:0005737 AmiGO QuickGO |
707305 |
| 3.4.21.61 | cytoplasm |
PC1 in striatum |
GO:0005737 AmiGO QuickGO |
683932 |
| 3.4.21.61 | extracellular |
- |
- |
732078 |
| 3.4.21.61 | extracellular |
secretion of the enzyme can be attenuated by annexin A2. Plasma concentration of the enzyme can be reduced by PPARalpha-dependent cleavage |
- |
731241 |
| 3.4.21.61 | extracellular |
the enzyme's prodomain inhibits intermolecular proteolysis in trans and requires the C-terminus for full inhibition and proper secretion, residue Val149 is critical for secretion |
- |
732152 |
| 3.4.21.61 | Golgi apparatus |
- |
GO:0005794 AmiGO QuickGO |
650257, 667421, 683695 |
| 3.4.21.61 | Golgi apparatus |
on its way through the Golgi and trans-Golgi complex, the enzyme co-localizes with the protein sortilin, in sortilin-knockout mice the plasma enzyme concentration is decreased, the protein-protein interaction is probably required for cellular secretion |
GO:0005794 AmiGO QuickGO |
731241 |
| 3.4.21.61 | Golgi apparatus |
on its way through the Golgi and trans-Golgi complex, the enzyme co-localizes with the protein sortilin, the protein-protein interaction is probably required for cellular secretion |
GO:0005794 AmiGO QuickGO |
731241 |
| 3.4.21.61 | Golgi apparatus |
trans Golgi network |
GO:0005794 AmiGO QuickGO |
650054, 651336 |
| 3.4.21.61 | membrane |
- |
GO:0016020 AmiGO QuickGO |
-, 29418, 29419, 29420, 29422 |
