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EC Number Localization Commentary GeneOntology No. Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22apoplast - GO:0048046 AmiGO QuickGO 751616
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22cytoplasm distributed within vacuoles GO:0005737 AmiGO QuickGO 646909
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22cytosol the molecular mechanism of diphtheria toxin catalytic domain entry into the eukaryotic cell cytosol is facilitated by target cell proteins GO:0005829 AmiGO QuickGO 716967
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22endoplasmic reticulum stably membrane-bound at 37°C, even under sodium carbonate treatment at pH 11.5, extractable at 20°C GO:0005783 AmiGO QuickGO 698877
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22extracellular saporin is largely secreted but some is retained intracellularly, most likely in a vacuolar compartment - 716541
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22extracellular Stx2 - 698253
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22extracellular the enzyme enters target cells via its cell surface receptor - 664166, 664245, 664265
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22extracellular the toxin is secreted - 664180
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22membrane - GO:0016020 AmiGO QuickGO 716963, 716967
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.22more the enzyme is synthesized as inactive precursor protein, accumulated in the endoplasmic reticulum associated to membranes, and needs to cleaved to the mature active form in the endoplasmic reticulum of the targeted cell, the mature form is retro-translocated from the ER to the cytosol where it is accumulated and escapes degradation, residues E176 and N70 are essential for catalytic activity - 664089
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