EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   2.3.1.78 | endosome |
HGSNAT coimmunoprecipitates with antibodies to ALIX, which is associated with the endosomal sorting complexes required for transport proteins |
GO:0005768 AmiGO QuickGO |
756105 |
| 2.3.1.78 | lysosomal membrane |
- |
GO:0005765 AmiGO QuickGO |
703972, 706441 |
| 2.3.1.78 | lysosomal membrane |
lysosomal transmembrane protein |
GO:0005765 AmiGO QuickGO |
676018 |
| 2.3.1.78 | lysosomal membrane |
transmembrane enzyme |
GO:0005765 AmiGO QuickGO |
661443 |
| 2.3.1.78 | lysosome |
- |
GO:0005764 AmiGO QuickGO |
487507, 671200, 756105 |
| 2.3.1.78 | lysosome |
enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate |
GO:0005764 AmiGO QuickGO |
487503, 487504, 487508 |
| 2.3.1.78 | lysosome |
integral membrane protein |
GO:0005764 AmiGO QuickGO |
487506, 487508 |
| 2.3.1.78 | lysosome |
membrane bound, about one fourth of the activity |
GO:0005764 AmiGO QuickGO |
487501 |
| 2.3.1.78 | lysosome |
the enzyme is synthesized as a catalytically inactive 77-kDa precursor that is transported to the lysosomes via an adaptor protein-mediated pathway that involves conserved tyrosine- and dileucine-based lysosomal targeting signals in its C-terminal cytoplasmic domain with a contribution from a dileucine-based signal in the N-terminal cytoplasmic loop. In the lysosome, the precursor is cleaved into a 29-kDa N-terminal alpha-chain and a 48-kDa C-terminal beta-chain, and assembled into active 440-kDa oligomers. The subunits are held together by disulfide bonds between at least two cysteine residues, Cys123 and Cys434, in the lysosomal luminal loops of the enzyme. |
GO:0005764 AmiGO QuickGO |
719889 |
| 2.3.1.78 | microsome |
membrane-bound, greater part of activity is recovered in microsomes |
- |
487501 |
