EC Number   |
Inhibitors |
Structure |
|---|
    6.6.1.1 | Mg2+ |
marked inhibition above 10 mM |
   |
| 6.6.1.1 | N-ethylmaleimide |
potent, IC50 of 0.02 mM |
|
| 6.6.1.1 | N-ethylmaleimide |
binds to ChlI subunit and inhibits its ATPase activity. The ChlI-ChlD-ATP complex forms but cannot catalyse magnesium chelation. Prior incubation with MgATP2- affords protection. Full protection can also be obtained with 5 mM ATP or 5 mM ADP alone |
|
| 6.6.1.1 | porphyrin |
at high ChlH concentrations, substrate inhibition is very noticeable |
|
| 6.6.1.1 | thiomerosal |
60% inhibition with 0.022 mM, in the absence of DTT |
|
| 6.6.1.1 | thioredoxin |
ATPase activity of recombinant CHLI1 is fully inactivated by oxidation and easily recovered by thioredoxin-assisted reduction |
|
| 6.6.1.1 | Urea |
20% inhibition with 100 mM, 50% inhibition with 250 mM, 90% inhibition with 800 mM |
|
