EC Number   |
Inhibitors |
Structure |
|---|
    5.5.1.13 | 2'-isopropyl-4'-(trimethylammonium chloride)-5'-methylphenyl-piperidine-1-carboxylate |
AMO-1618, a quaternary ammonium salt, leads to total enzyme inhibition at 0.001 mM |
   |
| 5.5.1.13 | 5-isopropyl-N,N,N,2-tetramethyl-4-[(1-piperidinylcarbonyl)oxy]anilinium chloride |
CPS1 activity exhibits approximately 70% inhibition by 0.1 mM Amo-1618, whereas the OsCPS2/OsCyc2 activity exhibits approximately 10% inhibition |
|
| 5.5.1.13 | AMO-1618 |
i.e. 2'-isopropyl-4'-(trimethylammoniumchloride)-5'-methylphenylpiperidine-1-carboxylate |
|
| 5.5.1.13 | Co2+ |
35-60% relative activity in the presence of 0.1 mM Co2+ compared to Mg2+ |
|
| 5.5.1.13 | EDTA |
inhibits activity in cell free extract containing the enzyme |
|
| 5.5.1.13 | Fe2+ |
5-10% relative activity in the presence of 0.1 mM Fe+ compared to Mg2+ |
|
| 5.5.1.13 | geranylgeranyl diphosphate |
inhibitory above 0.03 mM |
|
| 5.5.1.13 | geranylgeranyl diphosphate |
CPS1 but not CPS2/Cyc2 is inhibited by 0.05-0.06 mM geranylgeranyl diphosphate, CPS1 shows significant substrate inhibition in the presence of more than 0.05 mM geranylgeranyl diphosphate |
|
| 5.5.1.13 | Mg2+ |
weak inhibition of CPS2/Cyc2 at 5mM Mg2+ |
|
| 5.5.1.13 | more |
inhibitory effects on partially purified enzyme of 14 quaternary ammonium iodides at 3 different concentrations are reported |
|
