EC Number   |
Inhibitors |
Structure |
|---|
    5.3.1.1 | (1E,3E,6E,8E)-1,9-di(furan-2-yl)nona-1,3,6,8-tetraen-5-one |
compound binds to the dimer interface and is unable to inactivate Trypanosoma brucei TIM or Homo sapiens TIM at concentrations higher than 100 microM. Compound also affects cruzipain |
   |
| 5.3.1.1 | (1Z,2Z)-N,N'-dihydroxy-4-methylcyclohexa-3,5-diene-1,2-diimine |
- |
|
| 5.3.1.1 | (2E)-2-[(4-methyl-5-oxido-1,2,5-oxadiazol-3-yl)methylidene]hydrazinecarbothioamide |
- |
|
| 5.3.1.1 | (2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarbothioamide |
irreversible inhibitor |
|
| 5.3.1.1 | (2E)-2-[2-[(3-oxido-2,1,3-benzoxadiazol-5-yl)methoxy]benzylidene]-N-(prop-2-en-1-yl)hydrazinecarbothioamide |
irreversible inhibitor |
|
| 5.3.1.1 | (2E)-N-(naphthalen-2-yl)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinecarboxamide |
irreversible inhibitor |
|
| 5.3.1.1 | (2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxamide |
irreversible inhibitor |
|
| 5.3.1.1 | (2E,5E)-2,5-bis[(2E)-3-(thiophen-2-yl)prop-2-en-1-ylidene]cyclopentan-1-one |
compound is unable to inactivate Trypanosoma brucei TIM or Homo sapiens TIM at concentrations higher than 100 microM. Compound also affects cruzipain |
|
| 5.3.1.1 | (2E,6E)-2,6-bis[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]cyclohexan-1-one |
compound binds to the dimer interface and is unable to inactivate Trypanosoma brucei TIM or Homo sapiens TIM at concentrations higher than 100 microM. Compound also affects cruzipain |
|
| 5.3.1.1 | (4-methyl-1,2,3-thiadiazol-5-yl)methanol |
29% inhibition at 0.4 mM |
|
